Advances in Immunology, Vol. 53 by Frank J. Dixon (Ed.)

By Frank J. Dixon (Ed.)

For 30 years, this esteemed serial has supplied scholars and researchers with the most recent details in Immunology. you could proceed to depend upon Advances in Immunology to supply you with serious experiences that learn topics of significant significance to the sector via precis and review of present wisdom and examine. The articles pressure basic suggestions, but additionally assessment the experimental techniques. each one quantity of Advances in Immunology includes a topic index in addition to the contents of modern volumes. each one bankruptcy contains references. Researchers and scholars in microbiology, genetics and immunocology will use this precious serial to stick up to date at the most modern advances for future years. Key positive aspects * Advances in Immunology will maintain you trained on such generally outlined topics as: * Immunochemistry * Antibody synthesis * organic motion of antibodies * Immunological unresponsiveness * Mechanisms in innate and purchased immunity no longer regarding antibodies * really expert immunological strategies

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1992). The domain structure coninion to the heniatopoietin family of receptors is indicated. Thin horizontal lines correspond to cysteine residues conserved in the family and thick lines correspond to the WS x WS sequence motif. , transmembrane; cyto, cytoplasm. 46 DAVID P. GEARING pression is strongly enhanced by dexamethasone; however, LIF stimulation of the same gene is inhibited by dexamethasone (Baumann and Gauldie, 1990; Baumann et d . ,1992). Because OSM can bind the high-affinity LIF receptor in addition to an OSM-specific receptor, OSM would likely have the same range of effects as LIF (Gearing and Bruce, 1992) and then more.

266,20424-20427. , and Wong, G. C. (1989). Hepatocyte-stimulating factor I11 shares structural and functional identity with leukemia-inhibitory factor. J . Zmrnunol. 143, 11631167. , Won, K. , and Jahreis, G. P. (1989). Human hepatocyte-stimulating factor-111 and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins. J . Biol. Ckem. 264, 8046-8051. , Won, K. , Jones, V. , Campos, S. , Jahreis, G. , and Morella, K. K. (1992).

96. Wodnar-Filipowicz, A,, and Moroni, C. (1990). Regulation of interlenkin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions. Proc. Natl. Acad. S c i . 87, 777. 97. Henkel, G . , Weiss, D. , and Brown, M. A. (1992). J. Zmniunol. 149,3239. This article was accepted for publication on 23 September 1992. OGY. VOL 53 The Leukemia Inhibitory Factor and Its Receptor DAVID P. GEARING lmmunex Research and Development Corporation, Seattle, Washington 98101 I.

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